Thinking Small: Progress on Microscale Neurostimulation Technology

dc.contributor.ISNI0000 0000 2895 2047‏ (Cogan, SF)en_US
dc.contributor.VIAF43420545 (Cogan, SF)en_US
dc.contributor.authorPancrazio, Joseph J.en_US
dc.contributor.authorDeku, Felixen_US
dc.contributor.authorGhazavi, Atefehen_US
dc.contributor.authorStiller, Allison M.en_US
dc.contributor.authorRihani, Rasheden_US
dc.contributor.authorFrewin, Christopher L.en_US
dc.contributor.authorVarner, Victor D.en_US
dc.contributor.authorGardner, Timothy J.en_US
dc.contributor.authorCogan, Stuart F.en_US
dc.contributor.utdAuthorPancrazio, Joseph J.en_US
dc.contributor.utdAuthorDeku, Felixen_US
dc.contributor.utdAuthorGhazavi, Atefehen_US
dc.contributor.utdAuthorStiller, Allison M.en_US
dc.contributor.utdAuthorRihani, Rasheden_US
dc.contributor.utdAuthorFrewin, Christopher L.en_US
dc.contributor.utdAuthorVarner, Victor D.en_US
dc.contributor.utdAuthorGardner, Timothy J.en_US
dc.contributor.utdAuthorCogan, Stuart F.en_US
dc.descriptionFull text access from Treasures at UT Dallas is restricted to current UTD affiliates.en_US
dc.description.abstractObjectives: Neural stimulation is well-accepted as an effective therapy for a wide range of neurological disorders. While the scale of clinical devices is relatively large, translational, and pilot clinical applications are underway for microelectrode-based systems. Microelectrodes have the advantage of stimulating a relatively small tissue volume which may improve selectivity of therapeutic stimuli. Current microelectrode technology is associated with chronic tissue response which limits utility of these devices for neural recording and stimulation. One approach for addressing the tissue response problem may be to reduce physical dimensions of the device. "Thinking small" is a trend for the electronics industry, and for implantable neural interfaces, the result may be a device that can evade the foreign body response. Materials and Methods: This review paper surveys our current understanding pertaining to the relationship between implant size and tissue response and the state-of-the-art in ultrasmall microelectrodes. A comprehensive literature search was performed using PubMed, Web of Science (Clarivate Analytics), and Google Scholar. Results: The literature review shows recent efforts to create microelectrodes that are extremely thin appear to reduce or even eliminate the chronic tissue response. With high charge capacity coatings, ultramicroelectrodes fabricated from emerging polymers, and amorphous silicon carbide appear promising for neurostimulation applications. Conclusion: We envision the emergence of robust and manufacturable ultramicroelectrodes that leverage advanced materials where the small cross-sectional geometry enables compliance within tissue. Nevertheless, future testing under in vivo conditions is particularly important for assessing the stability of thin film devices under chronic stimulation.en_US
dc.description.departmentErik Jonsson School of Engineering and Computer Scienceen_US
dc.description.sponsorshipThe Space and Naval Warfare Systems Center, Pacific Grant/Contract No. HR0011-15-2-0017 and NIH grant U01NS090454-01en_US
dc.identifier.bibliographicCitationPancrazio, Joseph J., Felix Deku, Atefeh Ghazavi, Allison M. Stiller, et al. 2017. "Thinking small: Progress on microscale neurostimulation technology." Neuromodulation 20(8), 745-752, doi:10.1111/ner.12716en_US
dc.rights©2017 International Neuromodulation Societyen_US
dc.subjectDeep Brain Stimulationen_US
dc.subjectIridium oxideen_US
dc.subjectBrain-computer interfacesen_US
dc.titleThinking Small: Progress on Microscale Neurostimulation Technologyen_US


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