A protocol for the secure linking of registries for HPV surveillance

dc.contributor.authorEl Emam, Khaleden_US
dc.contributor.authorSamet, Saeeden_US
dc.contributor.authorHu, Junen_US
dc.contributor.authorPeyton, Liamen_US
dc.contributor.authorEarle, Craigen_US
dc.contributor.authorJayaraman, Gayatri C.en_US
dc.contributor.authorWong, Tomen_US
dc.contributor.authorKantarcioglu, Muraten_US
dc.contributor.authorDankar, Fidaen_US
dc.contributor.authorEssex, Aleksanderen_US
dc.description"This work was funded by the Canada Research Chairs program, the Ontario Institute for Cancer Research, a Collaborative Health Research Project grant from the Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council, an operating grant from CIHR, National Institutes of Health Grant 1R01LM009989, National Science Foundation (NSF) Grant Career-CNS-0845803, and NSF Grants CNS-0964350 and CNS-1016343."en_US
dc.description.abstractIntroduction: In order to monitor the effectiveness of HPV vaccination in Canada the linkage of multiple data registries may be required. These registries may not always be managed by the same organization and, furthermore, privacy legislation or practices may restrict any data linkages of records that can actually be done among registries. The objective of this study was to develop a secure protocol for linking data from different registries and to allow on-going monitoring of HPV vaccine effectiveness. Methods: A secure linking protocol, using commutative hash functions and secure multi-party computation techniques was developed. This protocol allows for the exact matching of records among registries and the computation of statistics on the linked data while meeting five practical requirements to ensure patient confidentiality and privacy. The statistics considered were: odds ratio and its confidence interval, chi-square test, and relative risk and its confidence interval. Additional statistics on contingency tables, such as other measures of association, can be added using the same principles presented. The computation time performance of this protocol was evaluated. Results: The protocol has acceptable computation time and scales linearly with the size of the data set and the size of the contingency table. The worse case computation time for up to 100, 000 patients returned by each query and a 16 cell contingency table is less than 4 hours for basic statistics, and the best case is under 3 hours. Discussion: A computationally practical protocol for the secure linking of data from multiple registries has been demonstrated in the context of HPV vaccine initiative impact assessment. The basic protocol can be generalized to the surveillance of other conditions, diseases, or vaccination programs. © 2012 El Emam et al.en_US
dc.identifier.citationEl Emam, Khaled, Saeed Samet, Jun Hu, Liam Peyton, et al. 2012. " A Protocol for the Secure Linking of Registries for HPV Surveillance ." PLOS One 7(7):e39915-1 to e39915-14.en_US
dc.rightsCC BY 3.0 (Attribution)en_US
dc.rights© 2012 El Emam et al.en_US
dc.source.journalPlos Oneen_US
dc.subjectPapillomavirus Vaccinesen_US
dc.subjectPublic Healthen_US
dc.subjectHealth Records, Personalen_US
dc.titleA protocol for the secure linking of registries for HPV surveillanceen_US


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