A Wearable Biochemical Sensor for Monitoring Alcohol Consumption Lifestyle Through Ethyl Glucuronide (EtG) Detection in Human Sweat

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A Wearable Biochemical Sensor for Monitoring Alcohol Consumption Lifestyle Through Ethyl Glucuronide (EtG) Detection in Human Sweat

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Title: A Wearable Biochemical Sensor for Monitoring Alcohol Consumption Lifestyle Through Ethyl Glucuronide (EtG) Detection in Human Sweat
Author(s):
Panneer Selvam, Anjan;
Muthukumar, Sriram;
Kamakoti, Vikramshankar;
Prasad, Shalini
Item Type: article
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Abstract: We demonstrate for the first time a wearable biochemical sensor for monitoring alcohol consumption through the detection and quantification of a metabolite of ethanol, ethyl glucuronide (EtG). We designed and fabricated two co-planar sensors with gold and zinc oxide as sensing electrodes. We also designed a LED based reporting for the presence of EtG in the human sweat samples. The sensor functions on affinity based immunoassay principles whereby monoclonal antibodies for EtG were immobilized on the electrodes using thiol based chemistry. Detection of EtG from human sweat was achieved through chemiresistive sensing mechanism. In this method, an AC voltage was applied across the two coplanar electrodes and the impedance across the sensor electrodes was measured and calibrated for physiologically relevant doses of EtG in human sweat. EtG detection over a dose concentration of 0.001-100  μg/L was demonstrated on both glass and polyimide substrates. Detection sensitivity was lower at 1 μg/L with gold electrodes as compared to ZnO, which had detection sensitivity of 0.001 μg/L. Based on the detection range the wearable sensor has the ability to detect alcohol consumption of up to 11 standard drinks in the US over a period of 4 to 9 hours.;
Publisher: Nature Publishing Group
ISSN: 2045-2322
Link to Related Resource: http://dx.doi.org/10.1038/srep23111
Persistent Link: http://dx.doi.org/10.1038/srep23111
http://hdl.handle.net/10735.1/5623
Bibliographic Citation: Panneer Selvam, Anjan, Sriram Muthukumar, Vikramshankar Kamakoti, and Shalini Prasad. 2016. "A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat." Scientific Reports 6(23111), doi:10.1038/srep23111
Terms of Use: CC BY 4.0 (Attribution)
©2016 The Authors. All Rights Reserved.

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CC BY 4.0 (Attribution) Except where otherwise noted, this item's license is described as CC BY 4.0 (Attribution)