Enhancing Executive Function and Neural Health in Bipolar Disorder Through Reasoning Training

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Enhancing Executive Function and Neural Health in Bipolar Disorder Through Reasoning Training

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title Enhancing Executive Function and Neural Health in Bipolar Disorder Through Reasoning Training
contributor.author Venza, Erin E. (UT Dallas)
contributor.author Chapman, Sandra Bond (UT Dallas)
contributor.author Aslan, Sina (UT Dallas)
contributor.author Zientz, Jennifer E. (UT Dallas)
contributor.author Tyler, David L. (UT Dallas)
contributor.author Spence, Jeffrey S. (UT Dallas)
contributor.ISNI 0000 0003 5170 3614 (Chapman, SB)
description ClinicalTrials.gov Identifier: NCT02843282
description.abstract Cognitive deficits in executive function and memory among individuals with bipolar disorder (BD) are well-documented; however, only recently have efforts begun to address whether such cognitive deficits can be ameliorated through cognitive training. This pilot study examined the effects of a top–down, cognitive reasoning training program in adults with BD on both brain and cognitive measures. Twenty-seven participants (11 males, 16 females), aged 21–70 years old, completed the study. Participants completed neurocognitive testing and functional magnetic resonance imaging (fMRI) before and after training, consisting of 8 h (2 h/week) of training in small groups. The training delivered information processing strategies that were implemented and applicable to a variety of daily living contexts. Results indicated that participants showed significant gains in the primary outcome measure of complex abstraction, also referred to as gist reasoning, as well as in untrained domains of executive function and memory. We found a significant increase in resting cerebral blood flow (CBF) in left inferior frontal gyrus after cognitive training. We also found that resting CBF in the right frontal middle gyrus correlated positively with performance on the measure of complex abstraction. This feasibility study provides promising evidence that short-term reasoning training can enhance cognitive performance and brain health in adults with BD. These data motivate further efforts to explore adjuvant therapeutics to improve cognitive performance and underlying brain systems in bipolar, as well as other psychiatric disorders.
description.sponsorship Dunlap family grant (#20249169)
identifier.issn 1664-1078
identifier.uri http://dx.doi.org/10.3389/fpsyg.2016.01676
identifier.uri http://hdl.handle.net/10735.1/5606
identifier.bibliographicCitation Venza, E., S. Chapman, A. Sina, J. Zientz, D. Tyler, J. Spence 2016. "Enhancing executive function and neural health in bipolar disorder through reasoning training." Frontiers in Psychology 7, doi: 10.3389/fpsyg.2016.01676
subject Manic-depressive illness
subject Cerebral circulation
subject Cognition
subject Cognitive therapy
subject Executive functions (Neuropsychology)
subject Neural networks (Neurobiology)
date.issued 2016-11-01
rights CC BY 4.0 (Attribution)
rights ©2016 The Authors. All Rights Reserved.
rights.uri http://creativecommons.org/licenses/by/4.0/

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CC BY 4.0 (Attribution) Except where otherwise noted, this item's license is described as CC BY 4.0 (Attribution)