A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism

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A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism

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Title: A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral Metabolism
Author(s):
Underwood, Erica L.;
Thompson, Lucien T.
Item Type: article
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Abstract: While high-fat diets are associated with rising incidence of obesity/type-2 diabetes and can induce metabolic and cognitive deficits, sex-dependent comparisons are rarely systematically made. Effects of exclusive consumption of a high-fat diet (HFD) on systemic metabolism and on behavioral measures of hippocampal-dependent memory were compared in young male and female LE rats. Littermates were fed from weaning either a HFD or a control diet (CD) for 12 wk prior to testing. Sex-different effects of the HFD were observed in classic metabolic signs associated with type-2 diabetes. Males fed the HFD became obese, and had elevated fasted blood glucose levels, elevated corticosterone, and impaired glucose-tolerance, while females on the HFD exhibited only elevated corticosterone. Regardless of peripheral metabolism alteration, rats of both sexes fed the HFD were equally impaired in a spatial object recognition memory task associated with impaired hippocampal function. While the metabolic changes reported here have been characterized previously in males, the set of diet-induced effects observed here in females are novel. Impaired memory can have significant cognitive consequences, over the short-term and over the lifespan. A significant need exists for comparative research into sex-dependent differences underlying obesity and metabolic syndromes relating systemic, cognitive, and neural plasticity mechanisms.
Publisher: Hindawi Publishing Corporation
ISSN: 2090-5904
Link to Related Resource: http://dx.doi.org/10.1155/2016/7385314
Persistent Link: http://hdl.handle.net/10735.1/4963
Bibliographic Citation: Underwood, E. L., and L. T. Thompson. 2016. "A high-fat diet causes impairment in hippocampal memory and sex-dependent alterations in peripheral metabolism." Neural Plasticity 2016, doi:10.1155/2016/7385314.
Terms of Use: CC BY 4.0 (Attribution) License
©2016 The Authors

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