Preliminary Findings Demonstrating Latent Effects of Early Adolescent Marijuana Use Onset on Cortical Architecture

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Preliminary Findings Demonstrating Latent Effects of Early Adolescent Marijuana Use Onset on Cortical Architecture

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title Preliminary Findings Demonstrating Latent Effects of Early Adolescent Marijuana Use Onset on Cortical Architecture
contributor.author Filbey, Francesca M. (UT Dallas)
contributor.author McQueeny, Tim (UT Dallas)
contributor.author DeWitt, Samuel J. (UT Dallas)
contributor.author Mishra, Virendra
contributor.ISNI 0000 0001 3618 6298 (Filbey, FM)
description.abstract Background: As the most commonly used illicit substance during early adolescence, long-term or latent effects of early adolescent marijuana use across adolescent developmental processes remain to be determined. Methods: We examined cortical thickness, gray/white matter border contrast (GWR) and local gyrification index (LGI) in 42 marijuana (MJ) users. Voxelwise regressions assessed early-onset (age = 16 years-old) differences and relationships to continued use while controlling for current age and alcohol use. Results: Although groups did not differ by onset status, groups diverged in their correlations between cannabis use and cortical architecture. Among early-onset users, continued years of MJ use and current MJ consumption were associated with thicker cortex, increased GWR and decreased LGI. Late-onset users exhibited the opposite pattern. This divergence was observed in all three morphological measures in the anterior dorsolateral frontal cortex (p < .05, FWE-corrected). Conclusions: Divergent patterns between current MJ use and elements of cortical architecture were associated with early MJ use onset. Considering brain development in early adolescence, findings are consistent with disruptions in pruning. However, divergence with continued use for many years thereafter suggests altered trajectories of brain maturation during late adolescence and beyond.
description.sponsorship This research was funded by the National Institute on Drug Abuse (R01 DA030344, Filbey).
identifier.issn 1878-9293
identifier.uri http://dx.doi.org/10.1016/j.dcn.2015.10.001
identifier.uri http://hdl.handle.net/10735.1/4960
identifier.bibliographicCitation Filbey, Francesca M., Tim McQueeny, Samuel J. DeWitt, and Virendra Mishra. 2015. "Preliminary findings demonstrating latent effects of early adolescent marijuana use onset on cortical architecture." Developmental Cognitive Neuroscience 16, doi:10.1016/j.dcn.2015.10.001.
identifier.volume 16
subject Adolescence
subject Cannabis
subject Marijuana Abuse
subject Malformations of Cortical Development
subject Gyrification
subject Morphology
subject Freesurfer (Computer file)
subject Cerebral Cortex
subject Age of Onset
subject White Matter
subject Cognitive Development
subject Young adults
subject Brain
date.issued 2015-10-09
publisher Elsevier Sci Ltd
rights CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives) License
rights ©2015 The Authors
rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
language.iso en
source.journal Developmental Cognitive Neuroscience

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CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives) License Except where otherwise noted, this item's license is described as CC BY-NC-ND 4.0 (Attribution-NonCommercial-NoDerivatives) License