Altered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptoms

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Altered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptoms

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title Altered Amygdala Connectivity in Individuals with Chronic Traumatic Brain Injury and Comorbid Depressive Symptoms
contributor.author Han, Kihwan (UT Dallas)
contributor.author Chapman, Sandra Bond (UT Dallas)
contributor.author Krawczyk, Daniel C. (UT Dallas)
contributor.ISNI 0000 0003 5170 3614 (Chapman, SB)
contributor.ORCID 0000-0002-4574-7306 (Han, K)
description.abstract Depression is one of the most common psychiatric conditions in individuals with chronic traumatic brain injury (TBI). Though depression has detrimental effects in TBI and network dysfunction is a "hallmark" of TBI and depression, there have not been any prior investigations of connectivity-based neuroimaging biomarkers for comorbid depression in TBI. We utilized resting-state functional magnetic resonance imaging to identify altered amygdala connectivity in individuals with chronic TBI (8 years post injury on average) exhibiting comorbid depressive symptoms (N = 31), relative to chronic TBI individuals having minimal depressive symptoms (N = 23). Connectivity analysis of these participant sub-groups revealed that the TBI-plus-depressive symptoms group showed relative increases in amygdala connectivity primarily in the regions that are part of the salience, somatomotor, dorsal attention, and visual networks P(voxel) < 0.01, P(cluster) < 0.025). Relative increases in amygdala connectivity in the TBI-plus-depressive symptoms group were also observed within areas of the limbic cortical mood regulating circuit (the left dorsomedial and right dorsolateral prefrontal cortices and thalamus) and the brainstem. Further analysis revealed that spatially dissociable patterns of correlation between amygdala connectivity and symptom severity according to subtypes (Cognitive and Affective) of depressive symptoms (p(voxel) < 0.01, p(duster) < 0.025). Taken together, these results suggest that amygdala connectivity may be a potentially effective neuroimaging biomarker for comorbid depressive symptoms in chronic TBI.
description.sponsorship "This work has been supported by Department of Defense CDMRP grants W81XWH-11-2-0194 to DCK and W81XWH-11-2-0195 to SBC and a grant from the Meadows Foundation to DCK and SBC."
description.uri Supplementary information available at: http://journal.frontiersin.org/article/10.3389/fneur.2015.00231
identifier.issn 1664-2295
identifier.uri http://hdl.handle.net/10735.1/4806
identifier.uri http://dx.doi.org/10.3389/fneur.2015.00231
identifier.bibliographicCitation Han, Kihwan, Sandra B. Chapman, and Daniel C. Krawczyk. 2015. "Altered amygdala connectivity in individuals with chronic traumatic brain injury and comorbid depressive symptoms." Frontiers In Neurology 6 (231), doi: 10.3389/fneur.2015.00231.
identifier.volume 6
identifier.issue 231
subject Brain Injuries
subject Depression
subject Magnetic Resonance Imaging
subject Amygdala
subject Battelle Developmental Inventory
subject Beck Depression Inventory-II
subject Intrinsic Functional Connectivity
subject Treatment-Resistant Depressive Disorder
subject Post-Traumatic Stress Disorders
subject Global Signal Regression
subject Prefrontal Cortex
subject Self-consciousness (Awareness)
subject Cerebral Cortex
date.issued 2015-11-04
publisher Frontiers Media S.A.
rights CC-BY 4.0 (Attribution) License
rights ©2015 The Authors
rights.uri http://creativecommons.org/licenses/by/4.0/
language.iso en
source.journal Frontiers in Neurology

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