Altered Cerebellar Connectivity in Parkinson's Patients ON and OFF L-DOPA Medication

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Altered Cerebellar Connectivity in Parkinson's Patients ON and OFF L-DOPA Medication

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Title: Altered Cerebellar Connectivity in Parkinson's Patients ON and OFF L-DOPA Medication
Author(s):
Festini, Sara B.;
Bernard, Jessica A.;
Kwak, Youngbin;
Peltier, Scott;
Bohnen, Nicolaas I.;
Müller, Martijn,L.T.M.;
Dayalu, Praveen;
Seidler, Rachael D.
Item Type: article
Keywords: Levodopa
Parkinson Disease
Cerebellum
Lobules
Description: Includes supplementary data.Article in other file formats available at Frontiers in Human Neuroscience website.
Abstract: Although nigrostriatal changes are most commonly affiliated with Parkinson's disease, the role of the cerebellum in Parkinson's has become increasingly apparent. The present study used lobule-based cerebellar resting state functional connectivity to (1) compare cerebellar-whole brain and cerebellar-cerebellar connectivity in Parkinson's patients both ON and OFF L-DOPA medication and controls, and to (2) relate variations in cerebellar connectivity to behavioral performance. Results indicated that, when contrasted to the control group, Parkinson's patients OFF medication had increased levels of cerebellar-whole brain and cerebellar-cerebellar connectivity, whereas Parkinson's patients ON medication had decreased levels of cerebellar-whole brain and cerebellar-cerebellar connectivity. Moreover, analyses relating levels of cerebellar connectivity to behavioral measures demonstrated that, within each group, increased levels of connectivity were most often associated with improved cognitive and motor performance, but there were several instances where increased connectivity was related to poorer performance. Overall, the present study found medication-variant cerebellar connectivity in Parkinson's patients, further demonstrating cerebellar changes associated with Parkinson's disease and the moderating effects of medication.;
Publisher: Frontiers Research Foundation
ISSN: 1662-5161
Persistent Link: http://dx.doi.org/10.3389/fnhum.2015.00214
http://hdl.handle.net/10735
Bibliographic Citation: Festini, Sara B., Jessica A. Bernard, Youngbin Kwak, Scott Peltier, et al. 2015. "Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication." Frontiers In Human Neuroscience 9(214): doi:10.3389/fnhum.2015.00214.
Terms of Use: CC-BY 4.0 (Attribution)
©2015 The Authors
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CC-BY 4.0 (Attribution) Except where otherwise noted, this item's license is described as CC-BY 4.0 (Attribution)