Long-Term Effects of Marijuana Use on the Brain

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Long-Term Effects of Marijuana Use on the Brain

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title Long-Term Effects of Marijuana Use on the Brain
contributor.author Filbey, Francesca M.
contributor.author Aslan, Sina
contributor.author Calhoun, Vince D.
contributor.author Spence, Jeffrey S.
contributor.author Damaraju, Eswar
contributor.author Caprihan, Arvind
contributor.author Segall, Judith
contributor.ISNI 0000 0001 3618 6298 (Filbey, FM)
contributor.ResID J-5163-2014 (Filbey, FM)
description.abstract Questions surrounding the effects of chronic marijuana use on brain structure continue to increase. To date, however, findings remain inconclusive. In this comprehensive study that aimed to characterize brain alterations associated with chronic marijuana use, we measured gray matter (GM) volume via structural MRI across the whole brain by using voxel-based morphology, synchrony among abnormal GM regions during resting state via functional connectivity MRI, and white matter integrity (i.e., structural connectivity) between the abnormal GM regions via diffusion tensor imaging in 48 marijuana users and 62 age- and sex-matched nonusing controls. The results showed that compared with controls, marijuana users had significantly less bilateral orbitofrontal gyri volume, higher functional connectivity in the orbitofrontal cortex (OFC) network, and higher structural connectivity in tracts that innervate the OFC (forceps minor) as measured by fractional anisotropy (FA). Increased OFC functional connectivity in marijuana users was associated with earlier age of onset. Lastly, a quadratic trend was observed suggesting that the FA of the forceps minor tract initially increased following regular marijuana use but decreased with protracted regular use. This pattern may indicate differential effects of initial and chronic marijuana use that may reflect complex neuroadaptive processes in response to marijuana use. Despite the observed age of onset effects, longitudinal studies are needed to determine causality of these effects.
description.sponsorship "This work was supported by National Institute on Drug Abuse Grant K01 DA021632."
identifier.citation Filbey, Francesca M., Sina Aslan, Vince D. Calhoun, Jeffrey S. Spence, et al. 2014. "Long-term effects of marijuana use on the brain." Proceedings of the National Academy of Sciences of the United States of America 111(47): 16913-16918.
identifier.issn 0027-8424
identifier.uri http://dx.doi.org/10.1073/pnas.1415297111
identifier.uri http://hdl.handle.net/10735.1/4420
identifier.volume 111
identifier.issue 47
subject Marijuana--Physiological effect
subject Diffusion tensor imaging
subject Magnetic resonance imaging
subject Prefrontal Cortex
date.issued 2014-11-25
publisher Natl Acad Sciences
rights ©2014 The Authors
language.iso en
source.journal Proceedings of the National Academy of Sciences of the United States of America

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