Fine-tuning Thermoresponsive Functional Poly(ε-caprolactone)s to Enhance Micelle Stability and Drug Loading

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Fine-tuning Thermoresponsive Functional Poly(ε-caprolactone)s to Enhance Micelle Stability and Drug Loading

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Title: Fine-tuning Thermoresponsive Functional Poly(ε-caprolactone)s to Enhance Micelle Stability and Drug Loading
Author(s):
Rainbolt, Elizabeth A.;
Miller, J. B.;
Washington, Katherine E.;
Senevirathne, Suchithra A.;
Biewer, Michael C. (UT Dallas);
Siegwart, D. J.;
Stefan, Mihaela C. (UT Dallas)
Format: Text
Item Type: Article
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Description: Supplementary information included.
Abstract: Block copolymers synthesized by the ring-opening polymerization of γ-2-[2-(2-methoxyethoxy)ethoxy]ethoxy-ε-caprolactone (ME₃CL), γ-2-methoxyethoxy-ε-caprolactone (ME₁CL), and ε-caprolactone (CL) are reported. Previously, diblock copolymers of PME₃CL-b-PME₁CL displayed excellent thermoresponsive tunability (31-43 ⁰C) and self-assembled into micelles with moderate thermodynamic stability. In this report, two strategies are employed to enhance thermodynamic stability of PME₃CL/PME₁CL-type block copolymer micelles while maintaining their attractive thermoresponsive qualities: modification of the end group position and alteration of hydrophobic block composition by using both ME₁CL and CL. These new thermoresponsive amphiphilic block copolymers showed lower critical micelle concentration (CMC) values by one order of magnitude and formed thermodynamically stable micelles. Furthermore they demonstrated good biocompatibility and up to 4.97 wt% doxorubicin loading, more than double the amount loaded into the PME₃CL-type polymeric micelles previously reported.
Publisher: Royal Society of Chemistry
ISSN: 2050-7518
Persistent Link: http://dx.doi.org/10.1039/c4tb02016b
http://hdl.handle.net/10735.1/4389
Bibliographic Citation: Rainbolt, E. A., J. B. Miller, K. E. Washington, S. A. Senevirathne, et al. 2015. "Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading." Journal of Materials Chemistry B 3(9): 1779-1787.
Terms of Use: ©2015 The Royal Society of Chemistry. This article may not be further made available or distributed.
Sponsors: "M.C.S. gratefully acknowledges financial support from the Welch Foundation (AT1740), and National Science Foundation (DMR-0956116 & CHE-1126177). D.J.S. gratefully acknowledges financial support from the Welch Foundation (I-1855) and CPRIT (R1212 and RP140110)."

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