Genome Wide Mapping of Foxo1 Binding-Sites in Murine T Lymphocytes

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Genome Wide Mapping of Foxo1 Binding-Sites in Murine T Lymphocytes

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Title: Genome Wide Mapping of Foxo1 Binding-Sites in Murine T Lymphocytes
Author(s):
Liao, Will;
Ouyang, Weiming;
Zhang, Michael Q. (UT Dallas);
Li, Ming O.
Item Type: Article
Keywords: Show Keywords
Abstract: The Forkhead box O (Foxo) family of transcription factors has a critical role in controlling the development, differentiation, and function of T cells. However, the direct target genes of Foxo transcription factors in T cells have not been well characterized. In this study, we focused on mapping the genome wide Foxo1-binding sites in naïve CD4(+) T cells, CD8(+) T cells, and Foxp3(+) regulatory T (Treg) cells. By using chromatin immunoprecipitation coupled with deep sequencing (ChIP-Seq), we identified Foxo1 binding sites that were shared among or specific to the three T cell populations. Here we describe the experiments, quality controls, as well as the deep sequencing data. Part of the data analysis has been published by Ouyang W et al. in Nature 20121] and Kim MV et al. in Immunity 20132], and the associated data set were uploaded to NCBI Gene Expression Omnibus.;
Publisher: Elsevier Inc
ISSN: 2213-5960
Persistent Link: http://hdl.handle.net/10735.1/4284
http://dx.doi.org/10.1016/j.gdata.2014.08.006
Terms of Use: CC-BY-NC-ND 3.0 (Attribution-NonCommercial-NoDerivatives)
©2014 The Authors
Sponsors: US National Institutes of Health (R01 AI102888/AI/NIAID)

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CC-BY-NC-ND 3.0 (Attribution-NonCommercial-NoDerivatives) Except where otherwise noted, this item's license is described as CC-BY-NC-ND 3.0 (Attribution-NonCommercial-NoDerivatives)