Chemoradiotherapeutic Wrinkled Mesoporous Silica Nanoparticles for use in Cancer Therapy

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Chemoradiotherapeutic Wrinkled Mesoporous Silica Nanoparticles for use in Cancer Therapy

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Title: Chemoradiotherapeutic Wrinkled Mesoporous Silica Nanoparticles for use in Cancer Therapy
Author(s):
Munaweera, Imalka;
Koneru, Bhuvaneswari;
Shi, Yi;
Di Pasqua, Anthony J.;
Balkus, Kenneth J., Jr.
Item Type: Article
Keywords: Cancer
Silica
Mesoporous materials
Nanoparticles
Description: Hi-res images available on publisher's site.
Abstract: Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo-and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, ¹H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation.
Publisher: Amer Inst Physics
ISSN: 2166-532X
Persistent Link: http://hdl.handle.net/10735.1/4258
http://dx.doi.org/10.1063/1.4899118
Terms of Use: CC-BY 3.0 (Attribution)

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CC-BY 3.0 (Attribution) Except where otherwise noted, this item's license is described as CC-BY 3.0 (Attribution)