Automatic and Reproducible Positioning of Phase-Contrast MRI for the Quantification of Global Cerebral Blood Flow

DSpace/Manakin Repository

Automatic and Reproducible Positioning of Phase-Contrast MRI for the Quantification of Global Cerebral Blood Flow

Show full item record

Title: Automatic and Reproducible Positioning of Phase-Contrast MRI for the Quantification of Global Cerebral Blood Flow
Author(s):
Liu, Peiying;
Lu, Hanzhang;
Filbey, Francesca M.;
Pinkham, Amy E.;
McAdams, Carrie J.;
Adinoff, Bryon;
Daliparthi, Vamsi;
Cao, Yan
Format: Text
Item Type: Article
Keywords: Show Keywords
Abstract: Phase-Contrast MRI (PC-MRI) is a noninvasive technique to measure blood flow. In particular, global but highly quantitative cerebral blood flow (CBF) measurement using PC-MRI complements several other CBF mapping methods such as arterial spin labeling and dynamic susceptibility contrast MRI by providing a calibration factor. The ability to estimate blood supply in physiological units also lays a foundation for assessment of brain metabolic rate. However, a major obstacle before wider applications of this method is that the slice positioning of the scan, ideally placed perpendicular to the feeding arteries, requires considerable expertise and can present a burden to the operator. In the present work, we proposed that the majority of PC-MRI scans can be positioned using an automatic algorithm, leaving only a small fraction of arteries requiring manual positioning. We implemented and evaluated an algorithm for this purpose based on feature extraction of a survey angiogram, which is of minimal operator dependence. In a comparative test-retest study with 7 subjects, the blood flow measurement using this algorithm showed an inter-session coefficient of variation (CoV) of 4.07 ± 3.03%. The Bland-Altman method showed that the automatic method differs from the manual method by between -8% and 11%, for 95% of the CBF measurements. This is comparable to the variance in CBF measurement using manually-positioned PC MRI alone. In a further application of this algorithm to 157 consecutive subjects from typical clinical cohorts, the algorithm provided successful positioning in 89.7% of the arteries. In 79.6% of the subjects, all four arteries could be planned using the algorithm. Chi-square tests of independence showed that the success rate was not dependent on the age or gender, but the patients showed a trend of lower success rate (p = 0.14) compared to healthy controls. In conclusion, this automatic positioning algorithm could improve the application of PC-MRI in CBF quantification.
Publisher: Public Library of Science
ISSN: 1932-6203
Source: PLOS One
Link to Related Resource: http://dx.doi.org/10.1371/journal.pone.0095721
Persistent Link: http://hdl.handle.net/10735.1/4089
Bibliographic Citation: Liu, Peiying, Hanzhang Lu, Francesca M. Filbey, Amy E. Pinkham, et al. 2014. "Automatic and Reproducible Positioning of Phase-Contrast MRI for the Quantification of Global Cerebral Blood Flow." PLOS One 9(5): e95721-1 to 10.
Terms of Use: CC BY 4.0 (Attribution)
©2014 The Authors
Sponsors: US National Institutes of Health (R01 MH084021; R01 NS067015; R21 AG034318; R01 AG042753; R21 NS078656; R01 DA023203). US National Science Foundation (DMS-0914910).

Files in this item

Files Size Format View
NSM-FR-YCao-271103.22.pdf 968.6Kb PDF View/Open Article

This item appears in the following Collection(s)


Show full item record

CC BY 4.0 (Attribution) Except where otherwise noted, this item's license is described as CC BY 4.0 (Attribution)