Assessment of Unconstrained Cerebrovascular Reactivity Marker for Large Age-Range fMRI Studies

DSpace/Manakin Repository

Assessment of Unconstrained Cerebrovascular Reactivity Marker for Large Age-Range fMRI Studies

Show full item record

Title: Assessment of Unconstrained Cerebrovascular Reactivity Marker for Large Age-Range fMRI Studies
Author(s):
Kannurpatti, S. S.;
Motes, Michael A.;
Biswal, B. B.;
Rypma, Bart
Item Type: article
Keywords: Show Keywords
Abstract: Breath hold (BH), a commonly used task to measure cerebrovascular reactivity (CVR) in fMRI studies varies in outcome among individuals due to subject-physiology and/or BH-inspiration/expiration differences (i.e., performance). In prior age-related fMRI studies, smaller task-related BOLD response variability is observed among younger than older individuals. Also, a linear CVR versus task relationship exists in younger individuals which maybe useful to test the accuracy of CVR responses in older groups. Hence we hypothesized that subject-related physiological and/or BH differences, if present, may compromise CVR versus task linearity in older individuals. To test the hypothesis, empirical BH versus task relationships from motor and cognitive areas were obtained in younger (mean age = 26 years) and older (mean age = 58 years) human subjects. BH versus task linearity was observed only in the younger group, confirming our hypothesis. Further analysis indicated BH responses and its variability to be similar in both younger and older groups, suggesting that BH may not accurately represent CVR in a large age range. Using the resting state fluctuation of amplitude (RSFA) as an unconstrained alternative to BH, subject-wise correspondence between BH and RSFA was tested. Correlation between BH versus RSFA was significant within the motor but was not significant in the cognitive areas in the younger and was completely disrupted in both areas in the older subjects indicating that BH responses are constrained by subject-related physiology and/or performance-related differences. Contrasting BH to task, RSFA-task relationships were independent of age accompanied by age-related increases in CVR variability as measured by RSFA, not observed with BH. Together the results obtained indicate that RSFA accurately represents CVR in any age range avoiding multiple and yet unknown physiologic and task-related pitfalls of BH.
Publisher: Public Library of Science
ISSN: 1932-6203
Persistent Link: http://dx.doi.org/10.1371/journal.pone.0088751
http://hdl.handle.net/10735.1/4085
Terms of Use: CC-BY 4.0 (Attribution)
Sponsors: US National Institutes of Health grants AG029523-02 (BR) and AG032088-02 (BB) and American Heart Association grant 0930132N (SK)

Files in this item

Files Size Format View
BBS-FR-BRypma-271099.40.pdf 805.3Kb PDF View/Open Article

This item appears in the following Collection(s)


Show full item record

CC-BY 4.0 (Attribution) Except where otherwise noted, this item's license is described as CC-BY 4.0 (Attribution)