A Typical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment

DSpace/Manakin Repository

A Typical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment

Show full item record

Title: A Typical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment
Author(s):
Brown, Timothy T.;
Erhart, Matthew;
Avesar, Daniel;
Dale, Anders M.;
Halgren, Eric;
Evans, Julia L.
Item Type: article
Keywords: Show Keywords
Abstract: Individuals with a diagnosis of specific language impairment (SLI) show abnormal spoken language occurring alongside normal non-verbal abilities. Behaviorally, people with SLI exhibit diverse profiles of impairment involving phonological, grammatical, syntactic, and semantic aspects of language. In this study, we used a multimodal neuroimaging technique called anatomically constrained magnetoencephalography (aMEG) to measure the dynamic functional brain organization of an adolescent with SLI. Using single-subject statistical maps of cortical activity, we compared this patient to a sibling and to a cohort of typically developing subjects during the performance of tasks designed to evoke semantic representations of concrete objects. Localized patterns of brain activity within the language impaired patient showed marked differences from the typical functional organization, with significant engagement of right hemisphere heteromodal cortical regions generally homotopic to the left hemisphere areas that usually show the greatest activity for such tasks. Functional neuroanatomical differences were evident at early sensoriperceptual processing stages and continued through later cognitive stages, observed specifically at latencies typically associated with semantic encoding operations. Our findings show with real-time temporal specificity evidence for an atypical right hemisphere specialization for the representation of concrete entities, independent of verbal motor demands. More broadly, our results demonstrate the feasibility and potential utility of using aMEG to characterize individual patient differences in the dynamic functional organization of the brain.
Publisher: Frontiers Research Foundation
ISSN: 1662-5161
Persistent Link: http://dx.doi.org/10.3389/fnhum.2014.00082
http://hdl.handle.net/10735.1/3998
Terms of Use: CC-BY 4.0 (Attribution)
Sponsors: National Institute of Neurological Disorders and Stroke (P50 NS022343); National Institute on Deafness and Other Communication Disorders (R01 DC005650)

Files in this item

Files Size Format View
BBS-FR-JLEvans-270968.96.pdf 1.425Mb PDF View/Open Article

This item appears in the following Collection(s)


Show full item record

CC-BY 4.0 (Attribution) Except where otherwise noted, this item's license is described as CC-BY 4.0 (Attribution)