A Novel Class of Polymeric pH-Responsive MRI CEST Agents

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A Novel Class of Polymeric pH-Responsive MRI CEST Agents

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Title: A Novel Class of Polymeric pH-Responsive MRI CEST Agents
Author(s):
Zhang, Shanrong;
Zhou, K.;
Huang, G.;
Takahashi, Masaya;
Sherry, A. Dean (UT Dallas);
Gao, Jinming
Item Type: Article
Keywords: Chemical Exchange Saturation Transfer (CEST)
Magnetic resonance imaging
Block copolymers
Micelles
Abstract: In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.
ISSN: 1359-7345
Persistent Link: http://hdl.handle.net/10735.1/3947
http://dx.doi.org/10.1039/C3CC42452A
Terms of Use: This article may not be further made available or distributed.

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