A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI

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A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI

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Title: A Europium(Ⅲ)-Based PARACEST Agent for Sensing Singlet Oxygen by MRI
Author(s):
Song, Bo;
Wu, Yunkou;
Yu, Mengxiao;
Zhao, Piyu;
Zhou, Chen;
Kiefer, Garry E.;
Sherry, A. Dean (UT Dallas)
Item Type: Article
Keywords: Active oxygen
Magnetic resonance imaging
Chemical Exchange Saturation Transfer (CEST)
Description: Includes supplementary material.
Abstract: A europium(Ⅲ) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ~3 ppm shift in the position of the Eu(Ⅲ)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.;
ISSN: 1477-9234
Persistent Link: http://hdl.handle.net/10735.1/3918
http://dx.doi.org/10.1039/C3DT50194A
Terms of Use: This article may not be further made available or distributed.

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