Neural effects of positive and negative incentives during marijuana withdrawal

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Neural effects of positive and negative incentives during marijuana withdrawal

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Title: Neural effects of positive and negative incentives during marijuana withdrawal
Author(s):
Filbey, Francesca M.;
Dunlop, Joseph;
Myers, Ursula S.
Format: text
Item Type: article
Keywords: Marijuana
Drug withdrawal symptoms
Amygdala
Drug addiction
Abstract: In spite of evidence suggesting two possible mechanisms related to drug-seeking behavior, namely reward-seeking and harm avoidance, much of the addiction literature has focused largely on positive incentivization mechanisms associated with addiction. In this study, we examined the contributing neural mechanisms of avoidance of an aversive state to drug-seeking behavior during marijuana withdrawal. To that end, marijuana users were scanned while performing the monetary incentive delay task in order to assess positive and negative incentive processes. The results showed a group x incentive interaction, such that marijuana users had greater response in areas that underlie reward processes during positive incentives while controls showed greater response in the same areas, but to negative incentives. Furthermore, a negative correlation between withdrawal symptoms and response in the amygdala during negative incentives was found in the marijuana users. These findings suggest that although marijuana users have greater reward sensitivity and less harm avoidance than controls, that attenuated amygdala response, an area that underlies fear and avoidance, was present in marijuana users with greater marijuana withdrawal symptoms. This is concordant with models of drug addiction that involve multiple sources of reinforcement in substance use disorders, and suggests the importance of strategies that focus on respective mechanisms.
ISSN: 1932-6203
Persistent Link: http://dx.doi.org/10.1371/journal.pone.0061470
http://hdl.handle.net/10735
Terms of Use: ©2013 The Authors. Creative Commons CC-BY license.
Sponsors: "This research was funded by a National Institute on Drug Abuse/National Institutes of Health grant: #KO1 DA021632 to Francesca Filbey. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."

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