Identifying Tinnitus-Related Genes based on a Side-Effect Network Analysis

DSpace/Manakin Repository

Identifying Tinnitus-Related Genes based on a Side-Effect Network Analysis

Show full item record

Title: Identifying Tinnitus-Related Genes based on a Side-Effect Network Analysis
Author(s):
Elgoyhen, A. B.;
Langguth, B.;
Nowak, W.;
Schecklmann, M.;
De Ridder, D.;
Vanneste, Sven
Format: text
Item Type: article
Keywords: Hyperacusis
Tinnitus
Hearing disorders
Hearing impaired
Abstract: Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug-target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.
Publisher: Nature Publishing Group
ISSN: 2163-8306
Persistent Link: http://dx.doi.org/10.1038/psp.2013.75
http://hdl.handle.net/10735
Terms of Use: ©2014 ASCPT. Licensed by a Creative Commons 3.0 BY-NC-ND.

Files in this item

Files Size Format View
BBS-FR-SVanneste-309522.44.pdf 567.6Kb PDF View/Open

This item appears in the following Collection(s)


Show full item record