Atypical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment

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Atypical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment

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Title: Atypical Right Hemisphere Specialization for Object Representations in an Adolescent with Specific Language Impairment
Author(s):
Brown, Timothy T.;
Erhart, Matthew;
Avesar, Daniel;
Dale, Anders M.;
Halgren, Eric;
Evans, Julia L.
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Item Type: article
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Abstract: Individuals with a diagnosis of specific language impairment (SLI) show abnormal spoken language occurring alongside normal non-verbal abilities. Behaviorally, people with SLI exhibit diverse profiles of impairment involving phonological, grammatical, syntactic, and semantic aspects of language. In this study, we used a multimodal neuroimaging technique called anatomically constrained magnetoencephalography (aMEG) to measure the dynamic functional brain organization of an adolescent with SLI. Using single-subject statistical maps of cortical activity, we compared this patient to a sibling and to a cohort of typically developing subjects during the performance of tasks designed to evoke semantic representations of concrete objects. Localized patterns of brain activity within the language impaired patient showed marked differences from the typical functional organization, with significant engagement of right hemisphere heteromodal cortical regions generally homotopic to the left hemisphere areas that usually show the greatest activity for such tasks. Functional neuroanatomical differences were evident at early sensoriperceptual processing stages and continued through later cognitive stages, observed specifically at latencies typically associated with semantic encoding operations. Our findings show with real-time temporal specificity evidence for an atypical right hemisphere specialization for the representation of concrete entities, independent of verbal motor demands. More broadly, our results demonstrate the feasibility and potential utility of using aMEG to characterize individual patient differences in the dynamic functional organization of the brain.;
Publisher: Frontiers Research Foundation
ISSN: 1662-5161
Link to Related Resource: http://dx.doi.org/10.3389/fnhum.2014.00082
Persistent Link: http://hdl.handle.net/10735.1/3629
Bibliographic Citation: Brown, Timothy T., Matthew Erhart, Daniel Avesar, Anders M. Dale, et al. 2014. "Atypical right hemisphere specialization for object representations in an adolescent with specific language impairment." Frontiers in Human Neuroscience 8(82): 1-11.
Terms of Use: © 2014 Brown, Erhart, Avesar, Dale, Halgren and Evans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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