Regulation of Morphogenesis and Neural Differentiation of Human Mesenchymal Stem Cells Using Carbon Nanotube Sheets

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Regulation of Morphogenesis and Neural Differentiation of Human Mesenchymal Stem Cells Using Carbon Nanotube Sheets

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Title: Regulation of Morphogenesis and Neural Differentiation of Human Mesenchymal Stem Cells Using Carbon Nanotube Sheets
Author(s):
Kim, Jeong Ah;
Jang, Eui Yun;
Kang, Tae June;
Yoon, Sungjun;
Ovalle-Robles, Raquel;
Rhee, Won Jong;
Kim, Taewoo;
Baughman, Ray H.;
Kim, Yong Hyup;
Park, Tai Hyun
Format: Text
Item Type: Article
Keywords: Nanofibers
Nanostructures
Myogenesis
Description: Includes Supplementary Information.
Abstract: In order to successfully utilize stem cells for therapeutic applications in regenerative medicine, efficient differentiation into a specific cell lineage and guidance of axons in a desired direction is crucial. Here, we used aligned multi-walled carbon nanotube (MWCNT) sheets to differentiate human mesenchymal stem cells (hMSCs) into neural cells. Human MSCs present a preferential adhesion to aligned CNT sheets with longitudinal stretch parallel to the CNT orientation direction. Cell elongation was 2-fold higher than the control and most of the cells were aligned on CNT sheets within 51 from the CNT orientation direction. Furthermore, a significant, synergistic enhancement of neural differentiation was observed in hMSCs cultured on the CNT sheets. Axon outgrowth was also controlled using nanoscale patterning of CNTs. This CNT sheet provides a new cellular scaffold platform that can regulate morphogenesis and differentiation of stem cells, which could open up a new approach for tissue and stem cell regeneration.
ISSN: 1757-9694
Source: Integrative Biology
Link to Related Resource: http://dx.doi.org/10.1039/c2ib20017a
Persistent Link: http://hdl.handle.net/10735.1/3103
Bibliographic Citation: Kim, Jeong Ah, Eui Yun Jang, Tae June Kang, Sungjun Yoon, et al. 2012. "Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets." Integrative Biology 4(6): 587-594.
Terms of Use: ©2013 The Royal Society of Chemistry. This article may not be further made available or distributed.

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